Ateneo Physics alumnus Dr. Adrian Serohijos in Science Daily 2008: Key Molecular Basis Of Cystic Fibrosis Identified Through Computer Simulations

Adrian Serohijos

Ateneo Physics alumnus Dr. Adrian Serohijos (BS Physics 2002 and BS Computer Engineering 2003), together with researchers from University of North Carolina at Chapel Hill, were featured in Science Daily for 2008 for their work on Cystic Fibrosis:

ScienceDaily (Mar. 3, 2008) — Researchers from the University of North Carolina at Chapel Hill have identified a key molecular mechanism that may account for the development of cystic fibrosis, which about 1 in 3000 children are born with in the US every year. The findings add new knowledge to understanding the development of this disease and may also point the way to new corrective treatments….

Using molecular dynamics simulations, the researchers performed extensive simulations of how normal and mutant NBD1 folded. Molecular dynamics simulation is akin to a “virtual experiment” wherein atoms and molecules are allowed to evolve according to known physical laws. Using computers, this virtual experiment allows researchers to view how atoms actually move. These simulations, when applied to the NBD1 protein, showed that the disease-causing mutant exhibits a higher misfolding tendency….

The first author of the study is Adrian Serohijos, a graduate student in the department of Physics and Astronomy at UNC and in the Molecular and Cellular Biophysics Program. Other co-authors in the study include John Riordan, Ph.D., co-discoverer of the CFTR gene and professor of biochemistry and biophysics, and Tamas Hegedus, Ph.D. of the UNC Cystic Fibrosis Research Center.

This study was supported in part by grants from the Cystic Fibrosis Foundation, the National Institutes of Health, and the American Heart Association.

Journal reference: Serohijos AWR, Hegedus T, Riordan JR, Dokholyan NV (2008) Diminished Self-Chaperoning Activity of the DF508 Mutant of CFTR Results in Protein Misfolding. PLoS Comput Biol 4(2): e1000008. doi:10.1371/journal.pcbi.1000008 http://www.ploscompbiol.org/doi/pcbi.1000008

Dr. Adrian Serohijos is currently taking his postdoctoral studies in Shakhnovich Biophysics Laboratory, Department of Chemistry and Chemical Biology, Harvard University.

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Physics News and Features from Ateneo de Manila University

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