Zoraida P. Aguilar, PhD of Ocean NanoTech LLC to give a talk this 16 Dec 2010 at Schmitt Hall: “Engineered anomaterials for Biomedical Applications”

 

Engineered Nanomaterials for Biomedical Applications

Room 109, Schmitt Hall, Chemistry Department, Ateneo de Manila University, 15 Dec 2010, 4:30 p.m.

by ZORAIDA P. AGUILAR
Director of R&D, Ocean NanoTech LLC, Springdale, AR

Abstract

Engineered nanomaterials (ENMs) such as quantum dots, metal nanoparticles such as gold and silver, metal oxides like tin oxide nanoparticles, magnetic nanoparticles, liposomes, etc are a new class of materials. These have unique properties that include 3-100 nm diameter, signal brightness, low photo bleaching, high magnetic and electric properties, broad excitation spectrum, narrow bandwidth, and simultaneous excitation of multiple fluorescent colors. Quantum dots are unique in their emission spectra even with the use of ordinary source of light while magnetic nanoparticles are unique because of their highly magnetic nature.

The unique advantages of quantum dots as fluorescent labels increase the brightness under photon-limited conditions where light intensities are severely attenuated by scattering and absorption. This permits detection down to single nanoparticle level that lead to reliable quantification of binding and transport phenomena. The cross section of some QDs that may be 60 times larger than that of organic dye results in brightness that can be one or two orders of magnitude higher improving detection limit. As a result, quantum dots are used in a broad range of applications including single molecule biophysics, biomolecular profiling, optical barcoding, in vivo and in vitro imaging, targeted drug delivery, and other medical applications.

The biomedical imaging application of quantum dots lead to the fluorescence detection of breast cancer cell, prostate cancer cells, etc. Magnetic iron oxide nanoparticles have been studied for drug delivery, capture and isolation of target cells, MRI contrast agents, etc. Various examples of these biomedical applications of engineered nanomaterials will be discussed.80

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